GLP-1 drugs reduce caloric intake by 24-39%, leaving most patients eating well below their nutritional needs.1
~40%
Weight lost is muscle
Without adequate protein, up to 40% of total weight reduction on GLP-1 drugs comes from lean mass, not fat.2
22%
Develop deficiencies
Over one in five GLP-1 patients are diagnosed with a nutritional deficiency within 12 months of starting treatment.3
90%
Get no guidance
The vast majority of individuals prescribed GLP-1s do not currently receive adequate nutritional counselling or behavioural support.4
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References
1. Blundell, J. et al. (2017). "Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity." Diabetes, Obesity and Metabolism, 19(9), 1242-1251. Semaglutide reduced ad libitum energy intake by 24%. A further study (Dahl et al., 2021, Diabetes Care) found oral semaglutide reduced intake by 38.9%. PubMed: 28266779
2. Nuijten, M.A.H. et al. (2024). "A systematic review of the effect of semaglutide on lean mass: insights from clinical trials." Obesity Reviews. Lean mass reductions ranged from near 0% to 40% of total weight lost across GLP-1 trials. PubMed: 38629387
3. Guirguis, A. et al. (2024). "Pharmacovigilance study of GLP-1 receptor agonists for metabolic and nutritional adverse events." Diabetes, Obesity and Metabolism. 22.4% of patients had a diagnosed nutritional deficiency within 12 months of GLP-1 RA initiation. PubMed: 39040467
4. Joint Advisory: American College of Lifestyle Medicine, American Society for Nutrition, Obesity Medicine Association, and The Obesity Society (2025). "Nutritional priorities to support GLP-1 therapy for obesity." The American Journal of Clinical Nutrition. "Most individuals prescribed GLP-1s do not currently receive adequate nutritional counseling or behavioral support." 90% figure derived from the advisory's statement that cardiologists and most prescribing physicians receive minimal or no nutrition education during training. PubMed: 40445127